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How much weight can you lose on Ozempic? How much weight you can lose with Ozempic depends on what dosage you are taking, and for how long. In clinical trials, it took 68 weeks for the average study participant to lose 33 pounds. It is important to note that these studies were done with lower doses of Ozempic (1 mg and 0.5 mg) but that as of March 2022, Ozempic has been FDA-approved to use at higher doses as well (up to 2 mg weekly). It isn’t clear if higher doses will lead to more weight loss. Always talk to your doctor about your weight loss goals to establish realistic and healthy health plans, and make sure to include any relevant personal or family history when it comes to high blood pressure or obesity treatment.